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CAS 148553-50-8 API Raw Materials Pregabalin C12H16N2S For Analysis Pharmaceuticals

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CAS 148553-50-8 API Raw Materials Pregabalin C12H16N2S For Analysis Pharmaceuticals

CAS 148553-50-8 API Raw Materials Pregabalin C12H16N2S For Analysis Pharmaceuticals
CAS 148553-50-8 API Raw Materials Pregabalin C12H16N2S For Analysis Pharmaceuticals CAS 148553-50-8 API Raw Materials Pregabalin C12H16N2S For Analysis Pharmaceuticals

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Product Details:
Place of Origin: China
Brand Name: wanjiang
Certification: COA/CE and so on
Model Number: 148553-50-8
Payment & Shipping Terms:
Minimum Order Quantity: 1kg
Price: discount price
Packaging Details: bag, cartons or drums
Delivery Time: 1-3 working days
Payment Terms: T/T, Western Union, MoneyGram,bitcoins , usdt, bank transfer
Supply Ability: 1000kg/week

CAS 148553-50-8 API Raw Materials Pregabalin C12H16N2S For Analysis Pharmaceuticals

Description
Purity: 99.9%min Mf: C8H17NO2
Cas No.: 148553-50-8 Einecs No.: 604-639-1
Appearance: White Crystalline Powder Molecular Weight: 159.23
Product Name: Pregabalin Packing: 1kg,25kg, Or As Requirements
Density: 0.997±0.06 G/cm3(Predicted) Melting Point: 194-196°C
Boiling Point: 274.0±23.0 °C(Predicted) Delivery Time: In Stock
Shelf Life: 2 Years Storage: Cool And Dry Place
MOQ: 1kg Whatsapp: +86 155 1212 0776
Wickr: Wjadmin
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148553-50-8 API Raw Materials

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Pregabalin C12H16N2S

White Powder CAS 148553-50-8 API Raw Materials Pregabalin C12H16N2S For Analysis Pharmaceuticals

 

description

 

Product Name:
pregabalin

 

Pregabalin

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whatsapp +8615512120776
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Synonyms: 3(S)-(AMINOMETHYL)-5-METHYLHEXANOIC ACID;(3S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID;PREGABALIN;Pregablin;3-(Aminomethyl)-5-methyl-hexanoic acid;PREDNISOLONESODIUMPHOSPHATE;(R)-Pregabalin;(S)-Pregabalin
CAS: 148553-50-8
MF: C8H17NO2
MW: 159.23
EINECS: 604-639-1
Mol File:

148553-50-8

 

 
 
pregabalin Pregalin is characterized by a good behavioural profile. This AED does not appear to have significant negative effects on mood or behaviour in patients with epilepsy, although depression has been reported in some patients (dose- dependent effects of mild- to- moderate intensity). A potential abuse or misuse of pregabalin has also been reported, with implications in terms of dependence and withdrawal. pregabalin is also associated with limited negative cognitive effects, mainly related to sedation, decreased arousal, decreased attention and concentration (dose- dependent effects of mild- to- moderate intensity).
uses Pregabalin has an approved indication and is widely used for the treatment of generalized anxiety disorder. Several randomized, double- blind, placebocontrolled trials found that pregabalin is an effective treatment for patients with generalized anxiety disorder and social anxiety disorder. Possible implications in the treatment of mood disorders and benzodiazepines dependence are emerging. Moreover, pregabalin may be a therapeutic agent for the treatment of alcohol abuse, in both withdrawal phase and relapse prevention.
Description As a follow-up to its g-aminobutyric acid (GABA) agonist gabapentin, Pfizer has developed and launched pregabalin for the treatment of epilepsy and neuropathic pain. Although pregabalin is a structural analog of GABA, it does not interact with GABA-A or GABA-B receptors or influence GABA uptake. The exact mechanism of action is unclear, but pregabalin may reduce excitatory neurotransmitter release by binding to the α2-δ protein subunit of voltage-gated calcium channels. The resulting inhibition of excess neuronal activity is believed to be the basis for pregabalin’s efficacy in epilepsy and neuropathic pain alleviation. Since the activity is attributed to the (S′)-enantiomer alone, an efficient asymmetric synthesis is employed for commercial production. The key step is the asymmetric hydrogenation of 3-cyano-5-methyl-3-hexenoic acid using a chiral rhodium catalyst to afford an intermediate that is enriched in the (S′)-enantiomer. The cyano group is ultimately reduced by routine hydrogenation with a nickel catalyst. Further enrichment of the final product is realized by selective recrystallization with (S′)-mandelic acid or simply recrystallizing from water/isopropanol. Compared to gabapentin, pregabalin is 2- to 10-fold more potent in various animal models. For example, in preventing maximal electroshock seizures (MES) in mice, pregabalin has an ED50 of 20 mg/kg p.o. versus 87 mg/kg for gabapentin. A comparable increase in potency is also observed in the rat MES model (ED50=1.8mg=kg p.o. for pregabalin versus 10.3 mg/kg for gabapentin). In addition, pregabalin’s linear pharmacokinetics (Cmax relates to dose) translates to better predictability of pharmacological effects. It has 90% oral bioavailability, with an elimination half-life of approximately 6 h. The primary route of excretion is via the renal system with negligible metabolism. Furthermore, its lack of activity at the cytochrome P450 enzymes was reflected in an absence of pharmacokinetic drug-drug interactions in relevant studies. In a placebocontrolled, fixed dose (up to 600mg/day) trial with pregabalin as an adjunctive therapy for epilepsy, 14 to 51% of patients showed at least a 50% decrease in seizure frequency with a clear dose-response relationship. In a flexible dosing group, (150 mg/day to 600 mg/day), the seizure reduction rate was 35.4%compared to 40.3% for a fixed dose of 600mg/day and 10.6% for placebo. The most common side effects were dizziness (29%) and somnolence (21%). In addition, weight gain (equal to or more than 7% increase from baseline) occurred in 40% of patients in the 12-week study; however, there was no affect on male fertility or efficacy of oral contraceptives in women. Regarding the use of pregabalin in treating painful diabetic peripheral neuropathy, oral administration of 300 and 600 mg/day t.i.d. was superior to placebo (39–48% compared to 15–18% with placebo) in relieving pain and improving pain-related sleep interference. While pregabalin was originally developed as an anticonvulsant for epilepsy, its success in treating neuropathic pain has led to its exploration in treating other CNS disorders, such as, anxiety, social phobia, and fibromyalgia.
CAS 148553-50-8 API Raw Materials Pregabalin C12H16N2S For Analysis Pharmaceuticals 0
Packing & Delivery
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Cas 148553 50 8 Organic Chemistry Intermediate Pregabalin Powder 99.99% Purity 0
 

 

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