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CAS 148553-50-8 Pregabalin Pain Relief Epilepsy Treatment Nervous System API

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CAS 148553-50-8 Pregabalin Pain Relief Epilepsy Treatment Nervous System API

CAS 148553-50-8 Pregabalin Pain Relief Epilepsy Treatment Nervous System API
CAS 148553-50-8 Pregabalin Pain Relief Epilepsy Treatment Nervous System API CAS 148553-50-8 Pregabalin Pain Relief Epilepsy Treatment Nervous System API

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Product Details:
Place of Origin: China
Brand Name: wanjiang
Certification: ISO,GMP, COA, MSDS
Model Number: 148553-50-8
Payment & Shipping Terms:
Minimum Order Quantity: 1kg
Price: usd
Packaging Details: cartons or drums
Delivery Time: 3-5 working days
Payment Terms: T/T, Western Union, MoneyGram,bitcoins , bank transfer
Supply Ability: 1000kg/week

CAS 148553-50-8 Pregabalin Pain Relief Epilepsy Treatment Nervous System API

Description
Purity: 99.9%min Type: Pharmaceutical Intermediates
Cas No.: 148553-50-8 Product Name: Pregabalin
Color: White Crystal Powder Storage: Cool And Dry Place
Shelf Life: 2 Years Application: Organic Intermediate
Moq: 1kg Whatsapp: +8615512120776
Wickr: Wjadmin

Pregabalin Lyrica Powder Cas 148553-50-8 Pregabalin Cas No.148553-50-8

Description 

 

Product Name:
pregabalin

 

wj@gzwjsw.com
whatsapp +8615512120776
 
Synonyms: 3(S)-(AMINOMETHYL)-5-METHYLHEXANOIC ACID;(3S)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID;PREGABALIN;Pregablin;3-(Aminomethyl)-5-methyl-hexanoic acid;PREDNISOLONESODIUMPHOSPHATE;(R)-Pregabalin;(S)-Pregabalin
CAS: 148553-50-8
MF: C8H17NO2
MW: 159.23
EINECS: 604-639-1
Mol File:

148553-50-8.mol

 

 
 
pregabalin Pregalin is characterized by a good behavioural profile. This AED does not appear to have significant negative effects on mood or behaviour in patients with epilepsy, although depression has been reported in some patients (dose- dependent effects of mild- to- moderate intensity). A potential abuse or misuse of pregabalin has also been reported, with implications in terms of dependence and withdrawal. pregabalin is also associated with limited negative cognitive effects, mainly related to sedation, decreased arousal, decreased attention and concentration (dose- dependent effects of mild- to- moderate intensity).
uses Pregabalin has an approved indication and is widely used for the treatment of generalized anxiety disorder. Several randomized, double- blind, placebocontrolled trials found that pregabalin is an effective treatment for patients with generalized anxiety disorder and social anxiety disorder. Possible implications in the treatment of mood disorders and benzodiazepines dependence are emerging. Moreover, pregabalin may be a therapeutic agent for the treatment of alcohol abuse, in both withdrawal phase and relapse prevention.
Description As a follow-up to its g-aminobutyric acid (GABA) agonist gabapentin, Pfizer has developed and launched pregabalin for the treatment of epilepsy and neuropathic pain. Although pregabalin is a structural analog of GABA, it does not interact with GABA-A or GABA-B receptors or influence GABA uptake. The exact mechanism of action is unclear, but pregabalin may reduce excitatory neurotransmitter release by binding to the α2-δ protein subunit of voltage-gated calcium channels. The resulting inhibition of excess neuronal activity is believed to be the basis for pregabalin’s efficacy in epilepsy and neuropathic pain alleviation. Since the activity is attributed to the (S′)-enantiomer alone, an efficient asymmetric synthesis is employed for commercial production. The key step is the asymmetric hydrogenation of 3-cyano-5-methyl-3-hexenoic acid using a chiral rhodium catalyst to afford an intermediate that is enriched in the (S′)-enantiomer. The cyano group is ultimately reduced by routine hydrogenation with a nickel catalyst. Further enrichment of the final product is realized by selective recrystallization with (S′)-mandelic acid or simply recrystallizing from water/isopropanol. Compared to gabapentin, pregabalin is 2- to 10-fold more potent in various animal models. For example, in preventing maximal electroshock seizures (MES) in mice, pregabalin has an ED50 of 20 mg/kg p.o. versus 87 mg/kg for gabapentin. A comparable increase in potency is also observed in the rat MES model (ED50=1.8mg=kg p.o. for pregabalin versus 10.3 mg/kg for gabapentin). In addition, pregabalin’s linear pharmacokinetics (Cmax relates to dose) translates to better predictability of pharmacological effects. It has 90% oral bioavailability, with an elimination half-life of approximately 6 h. The primary route of excretion is via the renal system with negligible metabolism. Furthermore, its lack of activity at the cytochrome P450 enzymes was reflected in an absence of pharmacokinetic drug-drug interactions in relevant studies. In a placebocontrolled, fixed dose (up to 600mg/day) trial with pregabalin as an adjunctive therapy for epilepsy, 14 to 51% of patients showed at least a 50% decrease in seizure frequency with a clear dose-response relationship. In a flexible dosing group, (150 mg/day to 600 mg/day), the seizure reduction rate was 35.4%compared to 40.3% for a fixed dose of 600mg/day and 10.6% for placebo. The most common side effects were dizziness (29%) and somnolence (21%). In addition, weight gain (equal to or more than 7% increase from baseline) occurred in 40% of patients in the 12-week study; however, there was no affect on male fertility or efficacy of oral contraceptives in women. Regarding the use of pregabalin in treating painful diabetic peripheral neuropathy, oral administration of 300 and 600 mg/day t.i.d. was superior to placebo (39–48% compared to 15–18% with placebo) in relieving pain and improving pain-related sleep interference. While pregabalin was originally developed as an anticonvulsant for epilepsy, its success in treating neuropathic pain has led to its exploration in treating other CNS disorders, such as, anxiety, social phobia, and fibromyalgia.

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CAS 148553-50-8 Pregabalin Pain Relief Epilepsy Treatment Nervous System API 0
Company Profile
Guangzhou Wanjiang Biotechnology Co., Ltd. is a young chemical enterprise full of vitality, potential and comprehensive
strength.The company is located in the center of politics, military, economy, culture and science and education in South China.We are a professional manufacturer engaged in the research, development, production, sales and service of surfactants, biological agents, organic chemistry, oilfield chemicals and disinfectant raw materials.We can offer a wide range of products to meet the changing needs of the market.Custom orders are welcome.We are committed to strict quality control and thoughtful customer service, and our experienced staff are always available to discuss your requirements and ensure complete customer satisfaction.With an annual production capacity of 10,000 tons/year, we can easily meet your large orders.If you are interested in any of our products or would like to place a custom order, please contact us.We will do our best to meet your needs. whatsapp+8615512120776
 
FAQ
 
1. who are we?
We are based in Guangdong, China, start from 2021,sell to North America(25.00%),South America(25.00%),Central America(25.00%),Eastern Europe(5.00%),Southeast Asia(5.00%),Mid East(5.00%),Western Europe(5.00%),Northern Europe(5.00%). There are total about 101-200 people in our office.

2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;

3.what can you buy from us?
btms50,80532-66-7,288573-56-8,5413-05-8,5449-12-7 ,

4. why should you buy from us not from other suppliers?
Our products are of high quality and competitive price, and we are highly recognized by our customers with high quality materials and excellent service.We are willing to work together with our business partners.

5. what services can we provide?
Accepted Delivery Terms: FOB,CFR,CIF,EXW,FAS,CIP,FCA,CPT,DEQ,DDP,DDU,Express Delivery,DAF,DES;
Accepted Payment Currency:USD,EUR,JPY,CAD,AUD,HKD,GBP,CNY,CHF;
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Language Spoken:English,Spanish,Japanese,Portuguese,German,Arabic,French,Russian,Korean,Hindi,Italian
 
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