Pharmacological pharmacokinetics
Although the chemical structure of cinnamic acid hydrochloride amide, but still and local anesthetic local esters, plasma cholinesterase can be hydrolyzed, clinically and can be used to identify the effect of the esterase. Local anesthesia than procaine 22 to 25 times, long duration, but the toxicity of procaine than 15-20 times, once poisoning, rescue takes 4-8 hours to reverse.
In the organization than procaine stable, so the duration of anesthesia for a long time (about three times that of procaine).

Indications
For epidural anesthesia and spinal anesthesia. This product is easy through the mucosa, but also for surface anesthesia, but because of its toxicity is too large (about 15 times higher than procaine), less for infiltration anesthesia.

Dosage and Usage
Limited to adult subarachnoid block, generally limited to 10mg, shall not exceed 15-20mg.
Preparation and specifications: hydrochloride injection 2ml: 10mg.

Topical dosage forms and their usage and dosage:
1. Cream 0.5%, applied to the skin affected area, each prescription for 24 hours, adult 30mg is limited to children 2.5 ~ 5.0mg.
2. Ointment 1%, for the hemorrhoid coated surface of the lesion, early, late and after a time.
Epidural anesthesia and spinal anesthesia with 0.2-0.25% solution, total 7.5-12mg; surface anesthesia with 0.05-0.2% solution; infiltration anesthesia with 0.01-0.1% solution, the total does not exceed 15mg.

Adverse reactions
Toxicity, may have nausea, sweating, difficulty breathing, delirium or delirium. High-dose use, convulsions, facial or skin flushing. Individual cases of allergic reactions.

Description :

Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia. It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.

Indications:

For epidural anesthesia and spinal anesthesia. This product is easy through the mucosa, but also for surface anesthesia, but because of its toxicity is too large (about 15 times higher than procaine), less for infiltration anesthesia.

Dosage and Usage；

Limited to adult subarachnoid block, generally limited to 10mg, shall not exceed 15-20mg.
Preparation and specifications: hydrochloride  injection 2ml: 10mg.

Topical dosage forms and their usage and dosage:

1. Cream 0.5%, applied to the skin affected area, each prescription for 24 hours, adult 30mg is limited to children 2.5 ~ 5.0mg.
2. Ointment 1%, for the hemorrhoid coated surface of the lesion, early, late and after a time. Epidural anesthesia and spinal anesthesia with 0.2-0.25% solution, total 7.5-12mg; surface anesthesia with 0.05-0.2% solution; infiltration anesthesia with 0.01-0.1% solution, the total does not exceed 15mg.

Adverse reactions
Toxicity, may have nausea, sweating, difficulty breathing, delirium or delirium. High-dose use, convulsions, facial or skin flushing. Individual cases of allergic reactions.

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