Local Anesthetic Raw Powder Ropivacaine hydrochloride CAS 132112-35-7

Quick details:

Product name: Ropivacaine hydrochloride
Synonyms: ROPIVCACAINE HYDROCHLORIDE; ROPIVACAINE HCL; (S)-ROPIVACAINE HYDROCHLORIDE; S-ROPIVACAINE HCL; N-(2, 6-dimethylphenyl)-1-propyl-piperidine-2-carboxamide hydrochloride; Ropivacaine mesilate; Ropivacaine hydrochloride; (2S)-N-(2, 6-dimethylphenyl)-1-propyl-pipecolinamide hydrochloride
Category: Pharmaceutical raw materials
Grade: Medical grade
Cas: 132112-35-7
MF: C17H26N2O. ClH. H2O
MW: 328.88
Assay: 98%
Packing: 25kg/drum
Character: White to off-white crystal or crystalline powder
Usage: Anesthetic

Description:
Ropivacaine is a local anaesthetic drug belonging to the amino amide group. The name ropivacaine refers to both the racemate and the marketed S-enantiomer.
Ropivacaine is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain.

Application:
Ropivacaine is used as a local (in only one area) anesthesia for a spinal block, also called an epidural. The medication is used to provide anesthesia during a surgery or C-section, or to ease labor pains.
Ropivacaine may also be used for purposes not listed in this medication guide.

Ropivacaine is indicated for local anaesthesia including infiltration, nerve block, epidural and intrathecal anaesthesia in adults and children over 12 years. It is also indicated for peripheral nerve block and caudal epidural in children 1-12 years for surgical pain. It is also sometimes used for infiltration anaesthesia for surgical pain in children.

Ropivacaine is often coadministered with for epidural analgesia, for example in pregnant women during.

Effect:
Ropivacaine blocks the initiation and conduction of nerve impulses by decreasing neuronal membrane permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of propagated action potentials and subsequent conduction blockade. The conduction blockade results in sensory and motor blockade. There is less motor blockade with ropivacaine as compared with bupivacaine.

Other actions/effects:

Ropivacaine may cause central nervous system (CNS) stimulation or depression, and cardiac depression. These effects are usually dose-related, and result from administration of large doses or unintentional intravascular injection of ropivacaine.

In in vitro and animal tests, ropivacaine caused more cardiac depression than , but less than bupivacaine.

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