Description

Lidoaine, also known as lignocaine and sold under the brand name Xylocaine among others, is a local anesthetic of the amino amide type. It is also used to treat ventricular tachycardia. When used for local anaesthesia or in nerve blocks, typically begins working within several minutes and lasts for half an hour to three hours. Lidoaine mixtures may also be applied directly to the skin or mucous membranes to numb the area.It is often used mixed with a small amount of adrenaline (epinephrine) to prolong its local effects and to decrease bleeding.

If injected intravenously, it may cause cerebral effects such as confusion, changes in vision, numbness, tingling, and vomiting.It can cause low blood pressure and an irregular heart rate.There are concerns that injecting it into a joint can cause problems with the cartilage.It appears to be generally safe for use in pregnancy.A lower dose may be required in those with liver problems.It is generally safe to use in those allergic to tetracaine or benzocaine.Lidocine is an antiarrhythmic medication of the class Ib type.This means it works by blocking sodium channels and thus decreasing the rate of contractions of the heart.When injected near nerves, the nerves cannot conduct signals to or from the brain.

Lidoaine was discovered in 1946 and went on sale in 1948.It is on the World Health Organization's List of Essential Medicines.It is available as a generic medication.In 2019, it was the 219th most commonly prescribed medication in the United States, with more than 2 million prescriptions.

Basic info

Numbering system

Lidoaine is a local anesthetic, also known as Xylocaine, in recent years it has been replaced procaine, widely used in local infiltration anesthesia in cosmetic plastic surgery, it can block the nerve excitability and conduction by inhibiting the sodium channels of nerve cell membrane. The fat soluble and protein binding rate of lidoaine is higher than procaine, its cell penetrating ability is strong, fast onset, long duration of action, the interaction strength is 4 times of procaine.
Lidoaine is used in infiltration anesthesia, epidural anesthesia, topical anesthesia (including thoracoscopy or abdominal surgery for mucosal anesthesia) and nerve block. In order to extend the time of anesthesia,  other side effects, can be added in the anesthetic epinephrine.
Lidoaine can also be used for the treatment of ventricular premature beat after acute myocardial infarction, ventricular tachycardia, digitalis poisoning, cardiac surgery and cardiac catheterization-induced ventricular arrhythmias, including ventricular premature beats, ventricular tachycardia and ventricular fibrillation. Lidoaine is also used for duration status of epilepsy which other anti-seizure drugs are not effective, as well as local or spinal anesthesia. But it is usually ineffective for supraventricular arrhythmias.

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