Strong effects var-denafil CAS 224785-90-4 white powder var-denafil base

Name: Strong effects var-denafil CAS 224785-90-4 white powder var-denafil base
Brand: wanjiang
SKU: 224785-90-4
Price: 25 USD
Availability: InStock
Rating: 5 (179 reviews)

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Strong effects var-denafil CAS 224785-90-4 white powder var-denafil base

Large Image : Strong effects var-denafil CAS 224785-90-4 white powder var-denafil base

Product Details:

Place of Origin:	China
Brand Name:	wanjiang
Certification:	ISO,GMP,COA, MSDS
Model Number:	224785-90-4

Payment & Shipping Terms:

Minimum Order Quantity:	500g
Price:	25-35usd/kg
Packaging Details:	1kg aluminum foil bag ,25kg drum or according to your request
Delivery Time:	within 2-3 working days after confirmation of your payment
Payment Terms:	Western Union, MoneyGram, T/T,bitcoin, USDT
Supply Ability:	5000kg/month

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Strong effects var-denafil CAS 224785-90-4 white powder var-denafil base

Description

Product Name:	Var-denafil	Appearance:	White Powder
Purity:	≥99%	Sample:	Available
Whatsapp:	+86 15512120776	Wickr:	Wjadmin
MF:	C23H32N6O4S	EINECS No:	607-088-5
MW:	488.6	Cas No.:	224785-90-4

Product Description ♠ ♠ ♠ ♠ ♠ ♠

Var-denafil is a new PDE5 inhibitor launched for oral treatment of male erectile dysfunction and it has significant structural similarity with sil-denafil (Via-gra?), which was the first PDE5 inhibitor introduced in 1998 for this indication. Var-denafil is synthesized in three steps starting with a cyclization reaction of 2-ethyoxybenzamidine with 2-butyramidopropionic acid and ethoxyallyl chloride to construct the imidazotriazine ring system, followed by sulfonation to the corresponding sulfonyl chloride and subsequent condensation with 1-ethylpiperazine. The potency of PDE5 inhibition by var-denafil (IC50=0.7 nM) is ～10 times greater than that of sil-denafil (IC50=6.6 nM). Var-denafil is typically administered in single doses of 10 and 20 mg. The time to reach maximum plasma concentration is 0.75 h, which is slightly shorter than those of sil-denafil (tmax=1.16 h) and tadala-fil (tmax=2h), and the half-life is 4–5 h. Although it is almost completely absorbed following oral administration, the mean absolute bioavailability of a 10 mg dose is ～15%, resulting from extensive first pass metabolism. Var-denafil is metabolized in the liver primarily by CYP3A4 and is eliminated mainly in feces. In clinical studies, 10–20 mg doses of var-denafil was well tolerated and efficacious in patients with ED of various severities, including subjects with comorbidities such as diabetes mellitus or hypertension or hyperlipidemia. The side-effect profile of var-denafil is similar to that of sil-denafil, with headache, flushing, dyspepsia and nasal congestion being the most common adverse events. Var-denafil has systemic vasodilatory properties, which can cause transient decrease in supine blood pressure; however, it does not appear to translate into clinical effects. The mean maximum decreases in supine systolic blood pressure following 20 and 40 mg var-denafil were 6.9 and 4.3 mmHg, respectively, when compared to placebo. However, single and multiple oral doses of var-denafil up to 40 mg produced no clinically relevant changes in the ECGs of normal male volunteers.

Var-denafil COA:

Test Items	Specification	Test Results
Description	White or almost white crystalline powder	White crystalline powder
Melting Point	191.0～193.0℃	192℃
Loss of drying	≤1.0%	0.5%
Heavy Metal	≤20ppm	15ppm
TLC	Only one spot	Only one spot
Assay	≥99.5%	99.96%
Conclusion	It complies with the USP 32.

Strong effects var-denafil CAS 224785-90-4 white powder var-denafil base 0

Natural Marigold Extract Xanthophyll CAS 127-40-2 Marigold Extract Lutein 0

PACKING & DELIVERY

Packaging	1kg-15kg packing	2 PE bag inside + 1 foil bag outside in carton
	25kg-50kg packing	2 PE bag inside + 1 foil bag outside in drum
	Other packing	Customized packing
Drum Size	D38cm*H60cm or customized, 25 kg/ drum
Shipping	1-50kg	International Express	Fast and convenient	Door to Door
	50-500kg	Air Transportation	Fast and cheap	To Air Port
	Above 500kg	Sea Transportation	Cheap and convenient	To Port

OUR ADVANTAGE:
1, High quality with competitive price:
1) Standard: Enterprise Standard
2) All Purity≥98%
3) We are manufacturer and can provide high quality products with factory price.
2, Fast and safe delivery
1) Parcel can be sent out within 24 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
3) Customs pass rate ≥99%
4) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.
3, We have clients throughout the world.
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Market feedback and goods feedback will be appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

FAQ
Q1. Can I have a sample order for your products?
A: Yes, we welcome sample order to test and check quality. Mixed samples are acceptable. We provide free samples, but the freight will be borne by you, and the cost will be returned to you or deducted from your order later.
Q2. What about the lead time?
A:Sample needs 3-5 days, mass production time needs 1-2 weeks for order quantity more than
Q3. Do you have any MOQ limit for order?
A: Low MOQ, 10-100g for sample checking is available
Q4. How do you ship the goods and how long does it take to arrive?
A: We usually ship by DHL, UPS, FedEx or TNT. It usually takes 3-5 days to arrive. Airline and sea shipping also optional.
Q5. How about the packing?
A: Usually we provide the packing as 25 kg / bag or carton. Of course, if you have special requirements on them, we will according to you.
Q6: how do you control quality?
A: We will make samples before mass production and start mass production after sample approval. 100% inspection during production and random inspection before packaging.
Q7: how to contact us?
A:Pls send us the product information you are interested in. You will get a reply within 24 hours. or contact us by Whatsapp/Telegram:+86 15512120776
Q8: which payment method do you accept?
A: For small orders, you can pay by wire transfer, Western Union, Moneygram transfer, Bank Tansfer, Bitcoin or Alibaba.
Q9: can you give me a discount?
A: Of course, it depends on your quantity
Q10: how to confirm product quality before placing an order?
A: you can get free samples for some products. You only need to pay for transportation or arrange express delivery to take samples for us. You can send us your product specifications and requirements. We will make products according to your requirements.
Q11: how do you deal with quality complaints?
A: first of all, our quality control will reduce the quality problem to nearly zero. If the actual quality problem is caused by
us, we will send you free goods for replacement or refund.
Q12: Are you trading company or manufacturer?
A: We are chemical factory in China. So we can provide wholesale price.

Welcome to send inquiry to us. Moderate price will be offered to you.

WhatsAPP/Telegram: +86 155 1212 0776
Wickr Me: wjadmin

Email: wj@gzwjsw.com

Tag:

Contact Person: Anna Sofia

Tel: +8615512120776

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