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Product Details:
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| Product Name: | Dihexa | Appearance: | White Powder |
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| Purity: | ≥99% | Sample: | Available |
| Whatsapp: | +86 15512120776 | Wickr: | Wjadmin |
| MF: | C27H44N4O5 | EINECS No: | 227-005-2 |
| MW: | 504.66 | Cas No.: | 1401708-83- 5 |
| High Light: | Dihexa 1401708-83- 5,Synthesis Dihexa Peptide Powder |
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| Contact: |
wj@gzwjsw.com
whatsapp +8615512120776
wickr:; wjadmin
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| Product Name: | Dihexa |
| Synonyms: | Dihexa;Hexanoyl-Tyr-Ile-Ahx-NH2;N-hexanoic-Try-Ile-(6)-amino hexanoic amide;PNB-0408;Dihexa (PNB-0408);N-(1-OXOHEXYL)-L-TYROSYL-N-(6-AMINO-6-OXOHEXYL)-L-ISOLEUCINAMIDE;L-Isoleucinamide, N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)- |
| CAS: | 1401708-83- 5 |
| MF: | C27H44N4O5 |
| MW: | 504.66 |
| EINECS: | 227-005-2 |
| Product Categories: | |
| Mol File: |
1401708-83- 5
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specification
| Description | Dihexa (developmental code name PNB-0408), also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, is an oligopeptide drug derived from angiotensin IV that binds with high affinity to hepatocyte growth factor (HGF) and potentiates its activity at its receptor, c-Met. The compound has been found to potently improve cognitive function in animal models of Alzheimer's disease-like mental impairment. In an assay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than brain-derived neurotrophic factor. |
| Uses | N-Hexanoic-Try-Ile-(6)-amino Hexanoic amide (Dihexa) is an angiotensin IV analog as a procognitive/antidementia agent. |
| Uses | Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease. |
| benefits | As a new drug, Dihexa has been highly seen to help people experiencing Alzheimer's Disease. Thus, it's main function is to relieve and supplement people who are stricken by this Disease to slow down the progression of Alzheimer's. The best thing about Dihexa is its ability to be able to repair damages found in the synapse that is just between the neurons. Here are some of the benefits of Dihexa: Helps people having Alzheimer's Disease and those with Parkinson's Disease Can increase your mental stamina Can improve creative thinking skills Can enhance conversational skills Can improve one's ability to solve problems Can help in managing depression Improves memory Dihexa also helps one improve focus and learning. That's why this is good most, especially for people who study too. It can even improve heart health, and also boost medical endurance. People who use Dihexa have had testimonies of how this peptide has helped improve their creativity, thinking, and even problem-solving skills. Although you must keep in mind that despite the benefits of Dihexa, it still has some side effects that you must be aware of primarily when it is being regularly used. One who even stops using Dihexa can have severe withdrawal effects once they decide to discontinue using this peptide. Some side effects could be unexpected jitters or even irritability. |
| Biological Activity | Dihexa is an orally active, blood-brain barrier-permeable angiotensin IV analog; exhibits high affinity binding hepatocyte growth factor (HGF) with a Kd of 65 pM. Dihexa binds with high affinity to HGF and both dihexa and its parent compound Norleucine 1-AngIV induce c-Met phosphorylation in the presence of subthreshold concentrations of HGF and augment HGF-dependent cell scattering. Further, dihexa and Nle1-AngIV induce hippocampal spinogenesis and synaptogenesis similar to HGF itself. Dihexa effectively inhibits HGF dimerization at 1 μM. While dihexa at 1 nM and 10 pM alone does not activate c-Met, it markedly augments the capacity of HGF at 1.25 and 2.5 ng/mL to activate c-Met. Dihexa has a long circulating half-life. Dihexa exhibits procognitive activity. Dihexa reverses scopolamine-dependent spatial learning deficits. It improves spatial learning in aged rats. Dihexa induces spinogenesis in cultured hippocampal neurons. |
| Clinical Use | Dihexa is a peptide variant derived from angiotensin IV which has been found to potently improve cognitive function in animal models of disease such as Alzheimer’s. Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and has been shown to enhance acquisition, consolidation, and recall of learning and memory in animal models when administered centrally or peripherally. In an essay of neurotrophic activity, Dihexa was found to be seven orders of magnitude more potent than BDNF. It could possibly help in the repair of the brain and nerves in neurological disease. |
| Mode of action | Being a first-class compound that is orally active, Dihexa works through penetrating the blood-brain barriers. This also works through facilitating one's memory consolidation and even memory retrieval. Researchers have seen how this peptide is very active. It also shows a very promising characteristic in terms of overcoming any memory and motor dysfunction. |
| Packing | 1kg/bag ,25kg/bag;25kg/drum; according to your requirements | |||
| Transit | Fedex, TNT,DHL,EMS,and so on. | |||
| Port | Shanghai/Tianjin/Dalian/Beijing/Xi'an | |||
| Lead Time | 1-3 working days upon received the payment | |||
| For mass orders, it will be delivered by air or sea. Depending on your location, please allow 1-5 business days for your order to arrive. For small order, please expect 3-7 days by UPS DHL EMS. For mass order, please allow 5-8 days by Air, 15-30 days by Sea. |
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Contact information:
Name: Anna Sofia
Whatsapp/ Telegram: +86 155 1212 0776
Signal: +86 155 1212 0776
Wickr: wjadmin
Wechat ID : wan68na
Email: wj@gzwjsw.com
Contact Person: Anna Sofia
Tel: +8615512120776
