ED Treatment Male Sex Enhancement CAS 330784-47-9 Avanafil Powder
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Product Name: Avanafil
Synonyms: (S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine;4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide;Avanafil;Avanafil (usan/inn);D03217;4-[[(3-Chloro-4-)Methyl] aMino]-2-[(2S)-2-(hydroxyMethyl)-1-pyrrolidinyl]-N-(2-pyriMidinylMethyl)-5-pyriMidinecarboxaMide;4-((3-chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide;(S)-4-((3-Chloro-4-Methoxybenzyl)aMino)-2-(2-(hydroxyMethyl)pyrrolidin-1-yl)-N-(pyriMidin-2-ylMethyl)pyriMidine-5-carboxaMide
CAS: 330784-47-9
MF: C23H26ClN7O3
MW: 483.95

Chemical Properties White Solid
Usage Avanafil is a highly selective PDE5 inhibitor with IC50 of 1 nM.
Usage A phosphodiesterase

Avanafil Applications:

Avanafil is a PDE5 inhibitor approved for erectile dysfunction by FDA on April 27, 2012 and by EMA on June 21, 2013. Avanafil acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum, as well as the retina. Other similar drugs . The advantage of avanafil is that it has very fast onset of action compared with other PDE5 inhibitors. It is absorbed quickly, reaching a maximum concentration in about 30–45 minutes. About two-thirds of the participants were able to engage in activity within 15 minutes.

Avanafil Functions:

an oral selective pde5 inhibitor indicated for the treatment of erection dysfunction. The average of effective time is 16 minutes. The plasma concentration can reach peak after two hours, the half-life is 18~48hours. Even is five days, the purity of can be tested in blood. The clinical report shows that it can be up to 83% after taking, and the dosage is 25-35mg. The main advantages are little side-effect, lasting for a long time and working strongly in two or three days.

Avanafil COA