Pharmaceutical Intermediate Tetracaine HCl Powder Pharmaceutical Chemical CAS 94-24-6 with Factory

Mechanism of Action:

Tetracaine acts by blocking the nerve systems. It does this by blocking the sodium ion channels needed for the conduction and initiation of neural impulses, thereby affecting the local anesthesia. Tetracaine acts by altering the function of calcium release channels that controls the release of calcium frim intracellular cells.

Application:
Tetracaine topical (for the skin) is used to numb various body parts before a surgical procedure or a medical test. Conversely, tetracaine ophthalmic drops are used as local anesthetic for the eyes.

General Description:
Tetracaine was developed to address the low potency andshort duration of action of procaine and chloroprocaine. The addition of the butyl side chain on the para nitrogen increasesthe lipid solubility of the drug and enhances the topical potencyof tetracaine. The plasma half-life is 120 to 150 seconds.Topically applied tetracaine to unbroken skin requires 30 to 45minutes to confer topical anesthesia. Tetracaine 4% gel is superiorthan eutectic mixture with  (EMLA) (an emulsionof  and prilocaine) in preventing pain associatedwith needle procedures in children. Tetracaine metabolism issimilar to procaine ester metabolism yielding parabutylaminobenzoicacid and dimethylaminoethanol and conjugatesexcreted in the urine. The pKa of the dimethylated nitrogen is8.4 and tetracaine is formulated as a hydrochloride salt with apH of 3.5 to 6.0. The increased absorption from topical siteshas resulted in reported toxicity.

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Relate Product:

These common effects and advantages of benzocaine:

• The remarkable feature of benzocaine is that it is easy to bind to the mucous membrane of the mucous membrane or skin surface, and it is not easy to enter the human body to produce toxicity.
• Benzocaine is an important organic synthesis intermediate. Mainly used in the production of medicine, plastics and coatings.
• Benzocaine has an anesthetic effect, based on which anesthetics such as oxoform, oxocaine and neo-osopron can be synthesized, and since then, many excellent local anesthetics of parabens have been synthesized. Analogs like procaine and many procaine. Such anesthetics have the advantages of good stability, fast onset, long maintenance time and small side effects, and thus are widely used.
• The main clinical applications of benzocaine are: temporary relief of pain and itching of the skin, mild burns, sunburn, trauma and bites. The otic preparation is used to alleviate the pain and itching of the acute congestive, concentrated otitis externa, swimming ear inflammation and external use of the ear. It is also effective for toothache, sore throat, mouth ulcers, various hemorrhoids, anal fissures, and genital itching. As a male genital desensitizer, ejaculation is slow. Or an anesthetic lubricant for catheters and endoscopes.

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