Properties Clenbuterol hydrochloride is a white or almost white crystalline powder; it is odorless and has a slightly bitter taste. It is soluble in water or ethanol, slightly soluble in chloroform or acetone, and insoluble in ether. Pharmacological effects Clenbuterol hydrochloride has a chemical structure similar to epinephrine drugs. It belongs to adrenergic drugs. It is a 2-receptor agonist. It has high selective activation of 2-receptors in bronchus, uterus and vascular smooth muscle. It can effectively relieve bronchospasm. In addition, it has a strong anti-allergic effect and significantly enhances bronchial cilia activity, and acts on lysosomes, which can promote mucus dissolution and facilitate the discharge of sputum. Clinically, it is mainly used for bronchial asthma and wheezing bronchitis. It has a strong and long-lasting effect. It is the main drug to prevent bronchial asthma and bronchospasm. Due to the small dosage of this drug (20-40g orally), and the rapid onset of effect after administration, It lasts for a long time, so this drug was included in the second part of the Pharmacopoeia of the People's Republic of China in 2000. The mechanism of action has been basically elucidated. Selective adrenaline β2 receptor agonist clenbuterol hydrochloride (clenbuterolhydrochloride), the appearance of white crystalline powder, the chemical name is hydroxymethyl-tert-butyl adrenaline or 2-[(tert-butylamino)methyl]-4-amino- 3,5-Dichlorobenzyl alcohol hydrochloride, the medicines are named diclo-fenac, albuterol, and clenbuterol. It is a potent and selective adrenergic β2 receptor agonist, which can relax bronchial smooth muscle and is used to treat bronchial asthma, asthmatic bronchitis and bronchitis with emphysema. The main ingredient of "Clenbuterol" is clenbuterol hydrochloride. Because it can promote protein synthesis in muscles, promote fat decomposition, and reduce fat accumulation, it can increase animal lean meat relatively, thereby improving the quality of livestock. Therefore, it is also called "growth promoter" and "nutrient re-partitioning agent". In the early 1960s, it was discovered that it could promote animal growth. In the 1970s, the United States introduced it into livestock and poultry production and became the most widely used β-stimulant in the world. However, due to the strong thermal stability and biochemical stability of the substance, after the animal eats it, it can form accumulated residues in the internal organs and tissues, and people will have symptoms of poisoning after eating pork containing clenbuterol. Therefore, countries around the world have banned the use of β-stimulants in animal husbandry soon, and many countries have developed detection methods for monitoring β-stimulant residues and clenbuterol in feed. The Chinese government banned Clenbuterol as a feed additive in 1997. Note: A small number of patients may have mild heart palpitations, hand tremors, dizziness and other adverse reactions, which will generally disappear gradually after continuing to take the drug. Use with caution in patients with hyperthyroidism, tachycardia or hypertension. Preparations: tablets, aerosols, suppositories, films, patches, etc. The above information is compiled by the Eastern editor of Chemicalbook. (2016-02-01) Figure 1 shows the structural use of clenbuterol hydrochloride for the prevention and treatment of bronchial spasm caused by bronchial asthma, chronic bronchitis and bronchitis with emphysema. Uses: It is used for the prevention and treatment of bronchial spasm caused by bronchial asthma, chronic bronchitis and bronchitis with emphysema. β2-adrenergic receptor agonist and bronchodilator. Category Toxic Substances Toxicity Classification High Toxicity Acute Toxicity Abdominal Cavity-Mice TDL0: 2 mg/kg Flammability Hazard Characteristics Flammable, decomposes toxic chlorides during combustion, nitrogen oxide gas storage and transportation characteristics Storehouse is low in temperature, ventilated, and dry; separate from food raw materials Store fire extinguishing agent water, carbon dioxide, dry powder, sand