whatsapp +8615512120776 local Anaesthesia Raw Procaine HCl Raw CAS 51-05-8

Product Name: Procaine hydrochloride
Synonyms: aminocaine;anadolor;anesthesol;anestil;atoxicocaine;Benzoicacid,monohydrochloride;benzoicacid,monohydrochloride;bernocaine
CAS: 51-05-8
MF: C13H21ClN2O2
MW: 272.77
EINECS: 200-077-2
Assay: 99%
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Chemical Properties:

Small, colorless crystals or white, crystalline powder; odorless; stable in air. Soluble in water and in alcohol at 25C; slightly soluble in chloroform; almost insoluble in ether; solutions acid to litmus. Because the ester bond in the structure can be hydrolyzed to produce p-aminobenzoic acid and diethylaminoethanol, under certain conditions, p-aminobenzoic acid can be further decarboxylated to produce toxic aniline. Procaine hydrochloride has aromatic primary amino groups in its structure, which can be easily oxidized and discolored. pH, temperature, ultraviolet light, oxygen and metal ions can accelerate the oxidation and discoloration.

Local anesthetic:

Procaine hydrochloride is a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.
The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0~5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ℃ steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.