CAS 61-12-1
EINECS number:200-498-1
Molecular formula:C20H31Cl2N3O2
Molecular weight:416.385
MP:99-101 º C
Boiling point:544.7 ° C at 760 mmHg
Flash Point:283.2 ° C
Vapor Pressure:3.37E-12mmHg at 25 ° C
Properties:
MP 99-101 ° C
Use:Anesthetic (local),Pharmaceutical raw materials
Packing:Foil bag or as requirments
English alias: Dibucaine, Nupercaine, Percaine Sovcaine
Drug categories: local anesthetics

1 . Basic info

2 . Description
Dibucaine hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted. The drug blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.

In combination sodium dibucaine hydrochloride is administered to dogs to induce rapid, humane, painless euthanasia. The euthanasia solution is toxic to wildlife. Euthanized animals must be properly disposed of by deep burial, incineration or other method in compliance with state and local laws

3 . Applications
Spinal anesthesia (high, low, saddle block) and topically to produce surface anesthesia. Eye: To anesthetize conjunctiva and cornea prior to superficial procedures (including tonometry, gonioscopy, removal of foreign bodies or sutures, corneal scraping).
Nose and Throat: To abolish laryngeal and esophageal reflexes prior to bronchoscopy, esophagoscopy.
Skin: To relieve pruritus, pain, burning.

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