Articaine Hydrochloride Articaine HCl Powder CAS 23964-57-0

Product Name	Articaine Hydrochloride
Synonyms	methyl 4-methyl-3-[[(1-oxo-2-(propylamino)propyl]amino]-2-thenoate monohydrochloride; Carticaine HCl; Ultracaine; CARTICAINE HYDROCHLORIDE; Ultracain;Articaine hydrochloride; Methyl 4-methyl-3-(2-propylaminopropanoylamino)thiophene-2-carboxylate hydrochloride; 4-methyl-3-[2-(propylamino)propanoylamino]thiophene-2-carboxylic acid methyl ester hydrochloride
CAS	23964-57-0
MF	C13H20N2O3S.ClH
MW	320.839
Purity	99% min
EINECS	245-957-7
Appearance	White Powder
Categories	Local anesthetic; Pharmaceutical intermediate

 

 

Product name: Articaine Hydrochloride ;Articaine HCl

CAS:23964-57-0

MF:C13H20N2O3S.HCl

MW:320.839

EINECS:245-957-7

Product Categories:local anesthetic;Pharmaceutical intermediate

Appearance: White crystalline powder

 

Trademark: Pharmlab

 

Original: China

 

Grade: Pharmaceutical grade

 

Certificate: ISO 9001, USP,GMP

 

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Description

 

Articaine is an intermediate-potency, short-acting amide local anesthetic with a fast metabolism due to an ester group in its structure. It is effective with local infiltration or peripheral nerve block in dentistry, when administered as a spinal, epidural, ocular, or regional nerve block, or when injected intravenously for regional anesthesia.

 

In comparative trials, its clinical effects were not generally significantly different from those of other short-acting local anesthetics like liddocaine, prilocaine, and chloroprocaine, and there is no conclusive evidence demonstrating above-average neurotoxicity. Articaine proved to be suitable and safe for procedures requiring a short duration of action in which a fast onset of anesthesia is desired, eg, dental procedures and ambulatory spinal anesthesia, in normal and in special populations.

 

Structure and metabolism

 

The amide structure of articaine is similar to that of other local anesthetics, but its molecular structure differs through the presence of a thiophene ring instead of a benzene ring. Articaine is exceptional because it contains an additional ester group that is metabolized by esterases in blood and tissue. The elimination of articaine is exponential with a half-life of 20 minutes. Since articaine is hydrolized very quickly in the blood, the risk of systemic intoxication seems to be lower than with other anesthetics, especially if repeated injection is performed.

 

 

 

 

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