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Cas 136-47-0 Tetracaine Hydrochloride Tetracaine Fine Chemical Intermediate

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Cas 136-47-0 Tetracaine Hydrochloride Tetracaine Fine Chemical Intermediate

Cas 136-47-0 Tetracaine Hydrochloride Tetracaine Fine Chemical Intermediate
Cas 136-47-0 Tetracaine Hydrochloride Tetracaine Fine Chemical Intermediate Cas 136-47-0 Tetracaine Hydrochloride Tetracaine Fine Chemical Intermediate

Large Image :  Cas 136-47-0 Tetracaine Hydrochloride Tetracaine Fine Chemical Intermediate

Product Details:
Place of Origin: china
Brand Name: wanjiang
Model Number: A-11
Payment & Shipping Terms:
Minimum Order Quantity: 1kg
Price: usd
Packaging Details: cartons or drums
Delivery Time: 3-5 working days
Payment Terms: T/T, Western Union, MoneyGram,bitcoins , bank transfer
Supply Ability: 1000kg/week

Cas 136-47-0 Tetracaine Hydrochloride Tetracaine Fine Chemical Intermediate

Description
Type: Anesthetic Agents Cas No.: 136-47-0
Other Names: Tetracaine Hcl Purity: 99%
Usage: Used As A Local Anesthetic Application: Fine Chemical Intermediate
Appearance: White Powder Shelf Life: 2 Years
Packing: Aluminum Foil Bag /drum Wickr: Wanjiang
High Light:

136-47-0 Tetracaine Hydrochloride

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Tetracaine Fine Chemical Intermediate

 

Cas 136-47-0 Tetracaine Hydrochloride Tetracaine Fine Chemical Intermediate

 
 
Product Details
cas 136-47-0 Tetracaine Hydrochloride Tetracaine Manufacturers China Local Anesthetic Agents
Product nameTetracaine hydrochloride
Molecular formulaC15H25ClN2O2
Molecular weight300.82
EINECS205-248-5
Melting point149°C
Density1.1279 (rough estimate)
Refractive index1.5200 (estimate)
Storage conditions2-8°C
Solubilityalcohol: solublesoluble 40 parts of solvent
Water SolubilitySoluble in water at 50mg/ml
Shelf life>12 Month

 
 
Description

Tetracaine hydrochloride (TCH) is one of the potent local anaesthetics. A kinetic study of oxidation of tetracaine hydrochloride by sodium N-chlorobenzenesulfonamide (chloramine-B or CAB) has been carried in HClO4 medium at 303 K. The rate shows first-order dependence on , shows fractional-order dependence on , and is self-governing on acid concentration. Decrease of dielectric constant of the medium, increased the rate. Variation of ionic strength and addition of benzenesulfonamide or NaCl have no significant effect on the rate. The reaction was studied at different temperatures and the activation parameters have been evaluated. The stoichiometry of the reaction was found to be 1 : 5 and the oxidation products were identified by spectral analysis. The conjugate free acid C6H5SO2NHCl of CAB is postulated as the reactive oxidizing species. The observed results have been explained by plausible mechanism and the related rate law has been deduced.

Delivery and Packing

25kg/drum,Cartons,Foil bags or as customer requirements . The goods of small quantity will be sent out in 3 working days. For bulk cargo, we will book the cargo space once the order is confirmed. Usually we will arrange the shipment in 7-15 days.
 

99% purity local anesthetics Pharmaceutical raw materials Tetracaine Hydrochloride/Tetracaine HCl CAS 136-47-0
 
Chemical Names: Tetracaine hydrochloride; Tetracaine HCl; Butethanol; Butylocaine; Anethain
CAS number: 136-47-0;
Molecular Formula: C15H25ClN2O2
Molecular Weight: 300.827 g/mol
 
Tetracaine (also known as amethocaine) is a local anesthetic of the ester anesthetic group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.
 
In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.[1]
 
Tetracaine is the T in TAC, a mixture of 5 to 12% tetracaine, 0.05% adrenaline,hydrochloride used in ear, nose, and throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.
 
 
1 Pharmacodynamic properties
Tetracaine hydrochloride is used as a local anaesthetic which acts by reversibly blocking the propagation and conduction of nerve impulses along nerve axons. Tetracaine stabilises the nerve membrane, preventing the increase in sodium permeability necessary for the production of an action potential.
5.2 Pharmacokinetic properties
Tetracaine is a weak base (pKa 8.5), therefore, significant changes in the rate of ionised lipid soluble drug uptake may occur with changes in the acid base balance.
In vitro studies have shown that tetracaine has a high affinity for melanin, therefore, differences in duration of action may be expected between deeply pigmented eyes and less pigmented eyes.
The primary site of metabolism for tetracaine is the plasma. Pseudocholinesterases in the plasma hydrolyse tetracaine to 4-aminobenzoic acid. Unmetabolised drug is excreted in the urine.
5.3 Preclinical safety data
No adverse safety issues were detected during the development of this formulation. The active ingredient is well established in clinical ophthalmology.

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Fast DeliveryDelivery within 24 hours upon receipt of your payment
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Cas 136-47-0 Tetracaine Hydrochloride Tetracaine Fine Chemical Intermediate 0
FAQ
Q1: Have your Product Quality been Approved by Third Party Lab?
A: Yes, All products are strictly tested by our QC, confirmed by QA and approved by third party lab in China, USA, Canada, Germany, UK, Italy, France etc. So you will be assured with Good Quality if you choose us.
Q2:How do you treat quality complaint?
A:First of all, our QC department will do strict examination of our export products by HPLC, UV, GC ,
TLC and so on in order to reduce the quality problem to near zero. If there is a real quality problem ,caused by us, we will send you free goods for replacement or refund your loss.
Q3: Do you Accept Sample Order?
A: Yes, we accept small order from 10g, 100g and 1kg for your evaluation quality of our goods.
Q4: Is there any discount?
A: Yes, for larger quantity, we always support with better price.
Q5:Do you accept VISA business credit card ?
A:Sorry we don't accept VISA credit card,
we accept bank transfer,Western Union and
Q6:How long does it take to the goods arrived ?
A:It is Depending on your location.For small order,please expect 5-7 days by DHL,UPS,TNT, FEDEX, EMS.For mass order,please allow 5-8 days by Air, 20-35 days by Sea.
Q7:Do you have any reshipment policy ?
we have good after-sale service and re-shipment policy if the parcel lose
Our long association with our clients has brought great benefits
We always take the upmost care in the packaging of our products
our clients will confirm this as even they struggle to find them without help at times.
But in spite of our best efforts it is still possible will seize a small number of packages.
In this circumstance we promise reship free to establish long term relationship
Q8:Can I get a sample?
A: Of course. For most products we can provide you a free sample, while the shipping cost shouldundertake by your side.
 

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